8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerica
DepartsWed, Apr 1st 2026
ReturnsThu, Apr 9th 2026
Nights8
Departing PortMemphis
Ports of CallMemphis, Mississippi River, Cleveland, Vicksburg, Natchez, St. Francisville, Cruising the River, Oak Alley, New Orleans
Launched in 2016, America is one of the finest Mississippi paddlewheelers ever built, introducing features never before seen on the Mississippi. America embodies a casual ambiance and relaxed atmosphere while providing panoramic views of the passing… 
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Heritage
DepartsSat, Apr 4th 2026
ReturnsSun, Apr 12th 2026
Nights8
Departing PortNew Orleans
Ports of CallNew Orleans, Oak Alley, Cruising the River, St. Francisville, Natchez, Vicksburg, Cleveland, Mississippi River, Memphis
Built in 2015, American Heritage, formerly Queen of the Mississippi, will receive a total ship redesign in time for the 2022 cruise season.
From the staterooms and suites to the lounges and dining rooms, American Heritage will be completely remodeled wit…
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Melody
DepartsSat, Apr 4th 2026
ReturnsSun, Apr 12th 2026
Nights8
Departing PortMemphis
Ports of CallMemphis, Mississippi River, Cleveland, Vicksburg, Natchez, St. Francisville, Cruising the River, Oak Alley, New Orleans
American Cruise Lines is pleased to announce the newest ship in our revolutionary series of modern riverboat series. American Melody will begin its inaugural season on the Mississippi River in the summer of 2021 and was specifically designed to navigate…
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Symphony
DepartsWed, Apr 8th 2026
ReturnsThu, Apr 16th 2026
Nights8
Departing PortMemphis
Ports of CallMemphis, Mississippi River, Cleveland, Vicksburg, Natchez, St. Francisville, Cruising the River, Oak Alley, New Orleans
The 180-passenger American Symphony introduces an updated modern interior design, integrating an elegant and refined aesthetic with our tradition for the spacious comfort found aboard all of our ships. Drawing inspiration from the geography acro…
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11 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Melody
DepartsWed, Apr 8th 2026
ReturnsSun, Apr 19th 2026
Nights11
Departing PortNew Orleans
Ports of CallNew Orleans, Cruising the River, Oak Alley, Baton Rouge, St. Francisville, Natchez, Vicksburg, Cruising the River, Cleveland, Tunica, Memphis (2 Days)
American Cruise Lines is pleased to announce the newest ship in our revolutionary series of modern riverboat series. American Melody will begin its inaugural season on the Mississippi River in the summer of 2021 and was specifically designed to navigate…
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Ocean View
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Heritage
DepartsFri, Apr 10th 2026
ReturnsSat, Apr 18th 2026
Nights8
Departing PortNew Orleans
Ports of CallNew Orleans, Oak Alley, Cruising the River, St. Francisville, Natchez, Vicksburg, Cleveland, Mississippi River, Memphis
Built in 2015, American Heritage, formerly Queen of the Mississippi, will receive a total ship redesign in time for the 2022 cruise season.
From the staterooms and suites to the lounges and dining rooms, American Heritage will be completely remodeled wit…
Inside Cabin
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Ocean View
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Balcony
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Suite
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsSat, Apr 11th 2026
ReturnsSun, Apr 19th 2026
Nights8
Departing PortMemphis
Ports of CallMemphis, Mississippi River, Cleveland, Vicksburg, Natchez, St. Francisville, Cruising the River, Oak Alley, New Orleans
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis…
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerica
DepartsWed, Apr 15th 2026
ReturnsThu, Apr 23rd 2026
Nights8
Departing PortMemphis
Ports of CallMemphis, Mississippi River, Cleveland, Vicksburg, Natchez, St. Francisville, Cruising the River, Oak Alley, New Orleans
Launched in 2016, America is one of the finest Mississippi paddlewheelers ever built, introducing features never before seen on the Mississippi. America embodies a casual ambiance and relaxed atmosphere while providing panoramic views of the passing…
Inside Cabin
Call for pricing
Ocean View
Call for pricing
Balcony
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Suite
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Heritage
DepartsThu, Apr 16th 2026
ReturnsFri, Apr 24th 2026
Nights8
Departing PortNew Orleans
Ports of CallNew Orleans, Oak Alley, Cruising the River, St. Francisville, Natchez, Vicksburg, Cleveland, Mississippi River, Memphis
Built in 2015, American Heritage, formerly Queen of the Mississippi, will receive a total ship redesign in time for the 2022 cruise season.
From the staterooms and suites to the lounges and dining rooms, American Heritage will be completely remodeled wit…
Inside Cabin
Call for pricing
Ocean View
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Balcony
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Suite
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Melody
DepartsSat, Apr 18th 2026
ReturnsSun, Apr 26th 2026
Nights8
Departing PortMemphis
Ports of CallMemphis, Mississippi River, Cleveland, Vicksburg, Natchez, St. Francisville, Cruising the River, Oak Alley, New Orleans
American Cruise Lines is pleased to announce the newest ship in our revolutionary series of modern riverboat series. American Melody will begin its inaugural season on the Mississippi River in the summer of 2021 and was specifically designed to navigate…
Inside Cabin
Call for pricing
Ocean View
Call for pricing
Balcony
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Suite
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Heritage
DepartsWed, Apr 22nd 2026
ReturnsThu, Apr 30th 2026
Nights8
Departing PortNew Orleans
Ports of CallNew Orleans, Oak Alley, Cruising the River, St. Francisville, Natchez, Vicksburg, Cleveland, Mississippi River, Memphis
Built in 2015, American Heritage, formerly Queen of the Mississippi, will receive a total ship redesign in time for the 2022 cruise season.
From the staterooms and suites to the lounges and dining rooms, American Heritage will be completely remodeled wit…
Inside Cabin
Call for pricing
Ocean View
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Balcony
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Suite
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsSat, Apr 25th 2026
ReturnsSun, May 3rd 2026
Nights8
Departing PortMemphis
Ports of CallMemphis, Mississippi River, Cleveland, Vicksburg, Natchez, St. Francisville, Cruising the River, Oak Alley, New Orleans
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis…
Inside Cabin
Call for pricing
Ocean View
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Balcony
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Suite
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Heritage
DepartsTue, Apr 28th 2026
ReturnsWed, May 6th 2026
Nights8
Departing PortNew Orleans
Ports of CallNew Orleans, Oak Alley, Cruising the River, St. Francisville, Natchez, Vicksburg, Cleveland, Mississippi River, Memphis
Built in 2015, American Heritage, formerly Queen of the Mississippi, will receive a total ship redesign in time for the 2022 cruise season.
From the staterooms and suites to the lounges and dining rooms, American Heritage will be completely remodeled wit…
Inside Cabin
Call for pricing
Ocean View
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Balcony
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Suite
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerica
DepartsWed, Apr 29th 2026
ReturnsThu, May 7th 2026
Nights8
Departing PortMemphis
Ports of CallMemphis, Mississippi River, Cleveland, Vicksburg, Natchez, St. Francisville, Cruising the River, Oak Alley, New Orleans
Launched in 2016, America is one of the finest Mississippi paddlewheelers ever built, introducing features never before seen on the Mississippi. America embodies a casual ambiance and relaxed atmosphere while providing panoramic views of the passing…
Inside Cabin
Call for pricing
Ocean View
Call for pricing
Balcony
Call for pricing
Suite
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Prices are per person, double occupancy, cruise only and on select sailings. Prices shown are for stateroom categories as noted and are shown in US Dollars. Pricing listed includes taxes and fees. Airfare is not included. Prices and itineraries are based on availability and are subject to change without notice.
