8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsSat, Oct 4th 2025
ReturnsSun, Oct 12th 2025
Nights8
Departing PortMemphis
Ports of CallMemphis, Mississippi River, Cleveland, Vicksburg, Natchez, St. Francisville, Cruising the River, Oak Alley, New Orleans
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis… 
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsSat, Oct 11th 2025
ReturnsSun, Oct 19th 2025
Nights8
Departing PortNew Orleans
Ports of CallNew Orleans, Oak Alley, Cruising the River, St. Francisville, Natchez, Vicksburg, Cleveland, Mississippi River, Memphis
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis…
Inside Cabin
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Ocean View
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Balcony
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Suite
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsFri, Oct 17th 2025
ReturnsSat, Oct 25th 2025
Nights8
Departing PortNew Orleans
Ports of CallNew Orleans, Mississippi River, Oak Alley, St. Francisville, Natchez, Vicksburg, Cleveland, Memphis (2 Days)
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis…
Inside Cabin
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Ocean View
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Balcony
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Suite
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsSat, Oct 18th 2025
ReturnsSun, Oct 26th 2025
Nights8
Departing PortMemphis
Ports of CallMemphis, Mississippi River, Cleveland, Vicksburg, Natchez, St. Francisville, Cruising the River, Oak Alley, New Orleans
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis…
Inside Cabin
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Ocean View
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Balcony
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Suite
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsFri, Oct 24th 2025
ReturnsSat, Nov 1st 2025
Nights8
Departing PortMemphis
Ports of CallMemphis, Mississippi River, Cleveland, Vicksburg, Natchez, St. Francisville, Cruising the River, Oak Alley, New Orleans
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis…
Inside Cabin
Call for pricing
Ocean View
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Balcony
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Suite
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7 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsSat, Oct 25th 2025
ReturnsSat, Nov 1st 2025
Nights7
Departing PortNew Orleans
Ports of CallNew Orleans, Oak Alley, Baton Rouge, St. Francisville, Natchez, Vicksburg, Mississippi River, Memphis
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis…
Inside Cabin
Call for pricing
Ocean View
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Balcony
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Suite
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11 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsFri, Oct 31st 2025
ReturnsTue, Nov 11th 2025
Nights11
Departing PortNew Orleans
Ports of CallNew Orleans, Cruising the River, Oak Alley, Baton Rouge, St. Francisville, Natchez, Vicksburg, Cruising the River, Cleveland, Tunica, Memphis (2 Days)
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis…
Inside Cabin
Call for pricing
Ocean View
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Balcony
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Suite
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Prices are per person, double occupancy, cruise only and on select sailings. Prices shown are for stateroom categories as noted and are shown in US Dollars. Pricing listed includes taxes and fees. Airfare is not included. Prices and itineraries are based on availability and are subject to change without notice.
