8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Melody
DepartsSat, May 2nd 2026
ReturnsSun, May 10th 2026
Nights8
Departing PortMemphis
Ports of CallMemphis, Mississippi River, Cleveland, Vicksburg, Natchez, St. Francisville, Cruising the River, Oak Alley, New Orleans
American Cruise Lines is pleased to announce the newest ship in our revolutionary series of modern riverboat series. American Melody will begin its inaugural season on the Mississippi River in the summer of 2021 and was specifically designed to navigate… 
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsSat, May 2nd 2026
ReturnsSun, May 10th 2026
Nights8
Departing PortNew Orleans
Ports of CallNew Orleans, Mississippi River, Oak Alley, St. Francisville, Natchez, Vicksburg, Cleveland, Memphis (2 Days)
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis…
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Heritage
DepartsMon, May 4th 2026
ReturnsTue, May 12th 2026
Nights8
Departing PortNew Orleans
Ports of CallNew Orleans, Oak Alley, Cruising the River, St. Francisville, Natchez, Vicksburg, Cleveland, Mississippi River, Memphis
Built in 2015, American Heritage, formerly Queen of the Mississippi, will receive a total ship redesign in time for the 2022 cruise season.
From the staterooms and suites to the lounges and dining rooms, American Heritage will be completely remodeled wit…
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerica
DepartsWed, May 6th 2026
ReturnsThu, May 14th 2026
Nights8
Departing PortNew Orleans
Ports of CallNew Orleans, Mississippi River, Oak Alley, St. Francisville, Natchez, Vicksburg, Cleveland, Memphis (2 Days)
Launched in 2016, America is one of the finest Mississippi paddlewheelers ever built, introducing features never before seen on the Mississippi. America embodies a casual ambiance and relaxed atmosphere while providing panoramic views of the passing…
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsSat, May 9th 2026
ReturnsSun, May 17th 2026
Nights8
Departing PortMemphis
Ports of CallMemphis, Mississippi River, Cleveland, Vicksburg, Natchez, St. Francisville, Cruising the River, Oak Alley, New Orleans
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis…
Inside Cabin
Call for pricing
Ocean View
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Balcony
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Suite
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Melody
DepartsSat, May 9th 2026
ReturnsSun, May 17th 2026
Nights8
Departing PortNew Orleans
Ports of CallNew Orleans, Mississippi River, Oak Alley, St. Francisville, Natchez, Vicksburg, Cleveland, Memphis (2 Days)
American Cruise Lines is pleased to announce the newest ship in our revolutionary series of modern riverboat series. American Melody will begin its inaugural season on the Mississippi River in the summer of 2021 and was specifically designed to navigate…
Inside Cabin
Call for pricing
Ocean View
Call for pricing
Balcony
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Suite
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Heritage
DepartsSun, May 10th 2026
ReturnsMon, May 18th 2026
Nights8
Departing PortNew Orleans
Ports of CallNew Orleans, Oak Alley, Cruising the River, St. Francisville, Natchez, Vicksburg, Cleveland, Mississippi River, Memphis
Built in 2015, American Heritage, formerly Queen of the Mississippi, will receive a total ship redesign in time for the 2022 cruise season.
From the staterooms and suites to the lounges and dining rooms, American Heritage will be completely remodeled wit…
Inside Cabin
Call for pricing
Ocean View
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Balcony
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Suite
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerica
DepartsWed, May 13th 2026
ReturnsThu, May 21st 2026
Nights8
Departing PortMemphis
Ports of CallMemphis, Mississippi River, Cleveland, Vicksburg, Natchez, St. Francisville, Cruising the River, Oak Alley, New Orleans
Launched in 2016, America is one of the finest Mississippi paddlewheelers ever built, introducing features never before seen on the Mississippi. America embodies a casual ambiance and relaxed atmosphere while providing panoramic views of the passing…
Inside Cabin
Call for pricing
Ocean View
Call for pricing
Balcony
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Suite
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Heritage
DepartsSat, May 16th 2026
ReturnsSun, May 24th 2026
Nights8
Departing PortNew Orleans
Ports of CallNew Orleans, Oak Alley, Cruising the River, St. Francisville, Natchez, Vicksburg, Cleveland, Mississippi River, Memphis
Built in 2015, American Heritage, formerly Queen of the Mississippi, will receive a total ship redesign in time for the 2022 cruise season.
From the staterooms and suites to the lounges and dining rooms, American Heritage will be completely remodeled wit…
Inside Cabin
Call for pricing
Ocean View
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Balcony
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Suite
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Melody
DepartsSat, May 16th 2026
ReturnsSun, May 24th 2026
Nights8
Departing PortMemphis
Ports of CallMemphis, Mississippi River, Cleveland, Vicksburg, Natchez, St. Francisville, Cruising the River, Oak Alley, New Orleans
American Cruise Lines is pleased to announce the newest ship in our revolutionary series of modern riverboat series. American Melody will begin its inaugural season on the Mississippi River in the summer of 2021 and was specifically designed to navigate…
Inside Cabin
Call for pricing
Ocean View
Call for pricing
Balcony
Call for pricing
Suite
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsSat, May 16th 2026
ReturnsSun, May 24th 2026
Nights8
Departing PortNew Orleans
Ports of CallNew Orleans, Mississippi River, Oak Alley, St. Francisville, Natchez, Vicksburg, Cleveland, Memphis (2 Days)
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis…
Inside Cabin
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Ocean View
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Balcony
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Suite
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerica
DepartsWed, May 20th 2026
ReturnsThu, May 28th 2026
Nights8
Departing PortNew Orleans
Ports of CallNew Orleans, Mississippi River, Oak Alley, St. Francisville, Natchez, Vicksburg, Cleveland, Memphis (2 Days)
Launched in 2016, America is one of the finest Mississippi paddlewheelers ever built, introducing features never before seen on the Mississippi. America embodies a casual ambiance and relaxed atmosphere while providing panoramic views of the passing…
Inside Cabin
Call for pricing
Ocean View
Call for pricing
Balcony
Call for pricing
Suite
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Heritage
DepartsFri, May 22nd 2026
ReturnsSat, May 30th 2026
Nights8
Departing PortNew Orleans
Ports of CallNew Orleans, Oak Alley, Cruising the River, St. Francisville, Natchez, Vicksburg, Cleveland, Mississippi River, Memphis
Built in 2015, American Heritage, formerly Queen of the Mississippi, will receive a total ship redesign in time for the 2022 cruise season.
From the staterooms and suites to the lounges and dining rooms, American Heritage will be completely remodeled wit…
Inside Cabin
Call for pricing
Ocean View
Call for pricing
Balcony
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Suite
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsSat, May 23rd 2026
ReturnsSun, May 31st 2026
Nights8
Departing PortMemphis
Ports of CallMemphis, Mississippi River, Cleveland, Vicksburg, Natchez, St. Francisville, Cruising the River, Oak Alley, New Orleans
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis…
Inside Cabin
Call for pricing
Ocean View
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Balcony
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Suite
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22 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Melody
DepartsSat, May 23rd 2026
ReturnsSun, Jun 14th 2026
Nights22
Departing PortNew Orleans
Ports of CallNew Orleans, Mississippi River, Oak Alley, Houmas House, Baton Rouge, St. Francisville, Natchez, Vicksburg, Greenville, Tunica, Memphis, Cape Girardeau, Mississippi River, St Louis, Mississippi River, Hannibal, Mississippi River, Muscatine, Dubuque, Mississippi River, Winona, Red Wing, Minneapolis/St. Paul
American Cruise Lines is pleased to announce the newest ship in our revolutionary series of modern riverboat series. American Melody will begin its inaugural season on the Mississippi River in the summer of 2021 and was specifically designed to navigate…
Inside Cabin
Call for pricing
Ocean View
Call for pricing
Balcony
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Suite
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerica
DepartsWed, May 27th 2026
ReturnsThu, Jun 4th 2026
Nights8
Departing PortMemphis
Ports of CallMemphis, Mississippi River, Cleveland, Vicksburg, Natchez, St. Francisville, Cruising the River, Oak Alley, New Orleans
Launched in 2016, America is one of the finest Mississippi paddlewheelers ever built, introducing features never before seen on the Mississippi. America embodies a casual ambiance and relaxed atmosphere while providing panoramic views of the passing…
Inside Cabin
Call for pricing
Ocean View
Call for pricing
Balcony
Call for pricing
Suite
Call for pricing
8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Heritage
DepartsThu, May 28th 2026
ReturnsFri, Jun 5th 2026
Nights8
Departing PortNew Orleans
Ports of CallNew Orleans, Oak Alley, Cruising the River, St. Francisville, Natchez, Vicksburg, Cleveland, Mississippi River, Memphis
Built in 2015, American Heritage, formerly Queen of the Mississippi, will receive a total ship redesign in time for the 2022 cruise season.
From the staterooms and suites to the lounges and dining rooms, American Heritage will be completely remodeled wit…
Inside Cabin
Call for pricing
Ocean View
Call for pricing
Balcony
Call for pricing
Suite
Call for pricing
8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsSat, May 30th 2026
ReturnsSun, Jun 7th 2026
Nights8
Departing PortNew Orleans
Ports of CallNew Orleans, Mississippi River, Oak Alley, St. Francisville, Natchez, Vicksburg, Cleveland, Memphis (2 Days)
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis…
Inside Cabin
Call for pricing
Ocean View
Call for pricing
Balcony
Call for pricing
Suite
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Prices are per person, double occupancy, cruise only and on select sailings. Prices shown are for stateroom categories as noted and are shown in US Dollars. Pricing listed includes taxes and fees. Airfare is not included. Prices and itineraries are based on availability and are subject to change without notice.
