14 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsSat, Sep 13th 2025
ReturnsSat, Sep 27th 2025
Nights14
Departing PortMinneapolis/St. Paul
Ports of CallMinneapolis/St. Paul, Red Wing, La Crosse, Dubuque, Davenport, Fort Madison, Hannibal, St Louis, Mississippi River, Memphis, Mississippi River, Vicksburg, Natchez, Baton Rouge, New Orleans
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis… 
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Melody
DepartsSat, Sep 13th 2025
ReturnsSun, Sep 21st 2025
Nights8
Departing PortSt Louis
Ports of CallSt Louis, Mississippi River, Hannibal, Cruising the River, Muscatine, Dubuque, Winona, Red Wing, Minneapolis/St. Paul
American Cruise Lines is pleased to announce the newest ship in our revolutionary series of modern riverboat series. American Melody will begin its inaugural season on the Mississippi River in the summer of 2021 and was specifically designed to navigate…
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7 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsFri, Sep 19th 2025
ReturnsFri, Sep 26th 2025
Nights7
Departing PortSt Louis
Ports of CallSt Louis, Hannibal, Fort Madison, Davenport, Dubuque, La Crosse, Red Wing, Minneapolis/St. Paul
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis…
Inside Cabin
Call for pricing
Ocean View
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Balcony
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Suite
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14 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsFri, Sep 26th 2025
ReturnsFri, Oct 10th 2025
Nights14
Departing PortMinneapolis/St. Paul
Ports of CallMinneapolis/St. Paul, Red Wing, La Crosse, Dubuque, Davenport, Fort Madison, Hannibal, St Louis, Mississippi River, Memphis, Mississippi River, Vicksburg, Natchez, Baton Rouge, New Orleans
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis…
Inside Cabin
Call for pricing
Ocean View
Call for pricing
Balcony
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Suite
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7 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Melody
DepartsFri, Sep 26th 2025
ReturnsFri, Oct 3rd 2025
Nights7
Departing PortSt Louis
Ports of CallSt Louis, Hannibal, Fort Madison, Davenport, Dubuque, La Crosse, Red Wing, Minneapolis/St. Paul
American Cruise Lines is pleased to announce the newest ship in our revolutionary series of modern riverboat series. American Melody will begin its inaugural season on the Mississippi River in the summer of 2021 and was specifically designed to navigate…
Inside Cabin
Call for pricing
Ocean View
Call for pricing
Balcony
Call for pricing
Suite
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Prices are per person, double occupancy, cruise only and on select sailings. Prices shown are for stateroom categories as noted and are shown in US Dollars. Pricing listed includes taxes and fees. Airfare is not included. Prices and itineraries are based on availability and are subject to change without notice.
